A 31phosphorous magnetic resonance spectroscopy study of diazepam does not affect brain phosphorous metabolism.

We utilized in vivo 3tPhosphorous magnetic resonance spectroscopy (3tp MRS) to deterraine whether acute administration of diazepam alters brain oxidative and phospholipid metabolism in normal subjects. A primary motivation for these experiments was to establish whether sedation with diazepam, which is often required for patients to be successfully studied with MRS, alters 3~p metabolites. We present here the results of an initial study of eight subjects using 10 mg of diazepam and a second study of ten subjects using 20 mg of diazepam.